Rabies is a fatal disease that attacks the nervous system, and is carried by many mammalian animals. Common infected are bats, raccoons, foxes, and of course skunks. This virus is found in the saliva of animals, and humans are commonly infected by bites rather than scratches. Due to this, be wary of animals behaving oddly, such as those that are unusually tame, aggressive, or are paralyzed. Skunks that are out during the day are extremely dangerous as these animals are nocturnal, and daytime walking skunks are very likely to have the rabies virus.
Rabies once contracted will stay dormant for weeks or months. But once symptoms start showing such as flu like symptoms, the disease will be 100% fatal. You must get treatment before symptoms show because only a small handful in history survived. Do not risk getting bit, and if you must wear proper protection such as thick pants, gloves, and preferably a thick jacket made of leather or similar material.